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Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 45-52 doi: 10.1007/s11684-011-0117-y

Abstract:

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia. In past decades, intensive studies on the biology and treatment of this disease have resulted in a remarkably thorough understanding of its pathogenesis and improvement of treatment outcomes. In particular, the introduction of all-trans retinoic acid to conventional chemotherapy improved dramatically the remission and survival rates of APL patients and consequently became the major treatment modality for it. In the last decade, the groundbreaking development of arsenic further improved the survival rate of APL patients. As the most active agent in APL, arsenic directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemia cells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the disease a potentially curable type of leukemia. More notably, the recent development of oral arsenic compounds may further enhance not only clinical outcomes but also the convenience of patients, which may dramatically change the APL clinical scenario in the near future.

Keywords： acute promyelocytic leukemia arsenic all-trans retinoic acid survival

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Review of aeroelasticity for wind turbine: Current status, research focus and future perspectives

Pinting ZHANG, Shuhong HUANG

Frontiers in Energy 2011, Volume 5, Issue 4, Pages 419-434 doi: 10.1007/s11708-011-0166-6

Abstract: reviewed and the aeroelastic models for wind turbine blade are described, based on which, the current research

Keywords： wind turbine aeroelasticity aeroelastic code

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Stem cell research in hepatocellular carcinoma

SUN Chengyi, ZUO Shi

Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 1-4 doi: 10.1007/s11684-008-0001-6

Abstract: In this review, we focus on the current status of liver stem cell research and their roles in carcinogenesis

Keywords： lineage hepato-pancreas differentiation block carcinogenesis current status

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Natural Gas Hydrate Exploration and Production Technology Research Status and Development Strategy

Fu Qiang,Zhou Shouwei and Li Qingping

Strategic Study of CAE 2015, Volume 17, Issue 9, Pages 123-132

Abstract: efficient development and environmental risks are equally important for developing the gas hydrate, so the researchThis paper reviews the research progress of natural gas hydrate exploration and trial mining technology

Keywords： natural gas hydrate exploration and production huge reserves research status development strategy

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Status of domestic gasification technology in China

Zhimin HUANG , Jiansheng ZHANG , Guangxi YUE ,

Frontiers in Energy 2009, Volume 3, Issue 3, Pages 330-336 doi: 10.1007/s11708-009-0021-1

Abstract: The process description, technology characteristics, research and development process, performance indexes

Keywords： domestic gasification technology research and development performance commercialization

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Research Status and Development of the Bowed-Twisted Blade for Turbomachines”"> A Review of "Research Status and Development of the Bowed-Twisted Blade for Turbomachines”

Chen Maozhang

Strategic Study of CAE 2000, Volume 2, Issue 6, Pages 94-94

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Image Engineering and Its Research Status in China

Zhang Yujin

Strategic Study of CAE 2000, Volume 2, Issue 8, Pages 91-94

Abstract: This work shows a general and up-to-date picture of the current status, progress trends and applicationIt also supplies useful information for readers doing research and/or application works in this field

Keywords： image engineering publication survey

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The Status of the US High-Temperature Gas Reactors Review

Andrew C. Kadak

Engineering 2016, Volume 2, Issue 1, Pages 119-123 doi: 10.1016/J.ENG.2016.01.026

Abstract: Despite high hopes and expectations, the current status is that high temperature reactors have been relegatedto completing research programs on advanced fuels, graphite and materials with no plans to build a demonstrationof HTGR development, including but not limited to insufficient government funding requirements for research

Keywords： Next-Generation Nuclear Plant (NGNP) Licensing Nuclear Regulatory Commission Energy Policy Act of 2005 Researchstatus

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Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 2, Pages 158-180 doi: 10.1007/s11465-017-0455-9

Abstract: As more research findings are published, such technologies now involve complicated systems engineering

Keywords： ultra-precision grinding ultra-precision cutting ultra-precision polishing research status in China development

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Research Progress in Proton Exchange Membrane Fuel Cell

Ren Xueyou

Strategic Study of CAE 2005, Volume 7, Issue 1, Pages 86-94

Abstract:

The developing status and research progress of PEMFC at home and abroad were outlined in the paper

Keywords： FC PEM bipolar board membrane electrode electrocatalyst developing status

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Research on Several Strategic Issues on Eco-Civilization Construction

The Comprehensive Research Group for Research on Several Strategic Issues on Eco-Civilization Construction

Strategic Study of CAE 2017, Volume 19, Issue 4, Pages 1-5 doi: 10.15302/J-SSCAE-2017.04.001

Abstract:

In order to comprehensively and deeply study the status of eco-civilizationenvironment, green production, green living, and green governance, this paper evaluates the eco-civilization statusFocusing on three research areas, including the carrying capacity of resources and environment and theThis research provides countermeasures and strategic suggestions for macro decision-making in eco-civilization

Keywords： ecological civilization development status evaluation resources and environmental carrying capacity

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Current status and prospects of reliability systems engineering in China

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 492-502 doi: 10.1007/s42524-021-0172-2

Abstract: This study provides a systematic overview of the advent and evolution of reliability systems engineering (RSE) in China, and the latest RSE development, that is, model-based RSE (MBRSE), is emphatically introduced. The establishment of the system architecture and conceptual models of MBRSE is first described. The fundamental theory and methodology of MBRSE are then elaborated, with a V-model as the core of this approach. The development of various MBRSE platforms and the effectiveness of their implementation over the past 30 years are presented. The prospective trends in the development of RSE in China are outlined.

Keywords： reliability effectiveness model-based systems engineering reliability systems engineering

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Status quo and outlook of reconfigurable research

Li Yufeng,Qiu Han,Lan Julong

Strategic Study of CAE 2008, Volume 10, Issue 7, Pages 82-89

Abstract: basic concepts of RTR and the current development of the FPGA, this paper summarizes the past major researchResearch directions and open problems are also discussed from the point of view of reconfigurable network

Keywords： internet reconfigurable router reconfigurable network programmable hardware

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Present status and progress of neoadjuvant chemoradiotherapy for esophageal cancer

Jing Liu, Jinbo Yue, Ligang Xing, Jinming Yu

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 172-179 doi: 10.1007/s11684-013-0268-0

Abstract:

Trimodality based on neoadjuvant chemoradiotherapy (nCRT) followed by surgery is gaining popularity as a treatment strategy for locally advanced esophageal cancer. In this review, we summarize the role of nCRT and the recommended nCRT regimens based on clinical trials and meta-analyses. We analyze the relationship of nCRT with pathologic complete response (pCR) and then identify potential predictive markers of response. Compared with surgery alone and neoadjuvant chemotherapy followed by surgery, trimodality provides longer survival and has the advantage of local control compared with definitive chemoradiotherapy. The standard regimen is a platinum-based regimen with a radiation dose range of 41.4–50.4βGy by conventional fractionation. Evidence shows that patients with pCR tend to live longer than non-responders, indicating that pCR is a significant prognostic factor for patients with esophageal cancer. Individualized medicine requires predictive markers of individual patients based on their own genes. Currently, no definite marker is proved to be sufficiently sensitive and specific for use in clinical practice, although 18-fluorodeoxyglucose positron emission tomography shows promise in predicting response to nCRT.

Keywords： esophageal cancer neoadjuvant chemoradiotherapy